BRCA Gene Testing FAQs and Expert Answers

You may have seen the term “BRCA 1 and BRCA 2 testing” being used in regards to a person’s risk for breast cancer, but are you unsure about what it means?

The simple explanation is this: BRCA1 and BRCA 2 are genes that help repair damaged DNA. Damaged DNA can lead to tumor growth. When either of these genes do not function properly, cells are more likely to develop genetic alterations that can lead to cancer.

It is possible to test for BRCA 1 & 2 mutations, but is it necessary for you? Having all of the information can help you make an informed decision.

How Much Does a BRCA 1 or 2 Mutation Affect Breast Cancer Risk?

Link between genetics and breast cancer disease

These specific genetic mutations greatly affect a woman’s risk of developing breast cancer. In women without a BRCA 1 or 2 mutation, the risk of developing breast cancer is approximately 12 percent. By the age of 70, women who have the BRCA 1 mutation have a 55 to 65 percent chance of developing breast cancer, and women who have the BRCA 2 mutation have a 45 percent chance.

It’s important to note that these risk percentages should only be used as a general guideline. Individual characteristics can cause an individual’s cancer risk rise or decrease.

Who Should Get a BRCA 1 & 2 Test?

Not everyone needs a BRCA 1 & 2 genetic test. These genetic mutations are somewhat rare in the general population, and because of this, widespread testing is unnecessary and expensive.

However, according to the National Cancer Institute, anyone with a family member who exhibits the following symptoms may be more likely to have one of the BRCA mutations:

  • Breast cancer diagnosed before age 50 years
  • Cancer in both breasts in the same woman
  • Both breast and ovarian cancers in either the same woman or the same family
  • Multiple breast cancers
  • Two or more primary types of BRCA1- or BRCA2-related cancers in a single family member
  • Cases of male breast cancer
  • Ashkenazi Jewish ethnicity

What Happens After Test Results?

For women who decide to get tested, their physician will be able to help plan their future health plan accordingly. For those who test positive for the BRCA 1 or 2 mutation, it is typically advised that they begin receiving enhanced screenings for breast cancer. This means that the patient will be given breast screenings at a younger age and more frequently than the standard recommendations.

Enhanced screenings will increase the physician’s chance of detecting breast cancer in its early stages, which may result in more effective treatment and higher survival rates.

Discussions With Your OBGYN Are Key

There’s no single rule to follow to determine whether or not genetic testing is right for you. If you have concerns about your family history or your breast cancer risk, speak with a provider at Women’s Care OBGYN to answer any questions and evaluate your testing options. To schedule an appointment, please call (913) 384-4990.